Latest News from the Lab
New work in Nature Communications (in Press)!!.
Collaborative work on "Hi-Q Brain Organoids" —A new class of stress-free brain organoids solves inherent problems of brain organoids such as heterogeneity, poor reproducibility, ectopic cellular stress, scalability (over thousands in one go), and biobanking. Hi-Q organoids are suitable for disease modeling, glioma invasion assays, and drug screening.
What is next?
High-throughput disease modeling of ciliary mutants and brain tissue repository for the community. Stay tuned!!
Post-doc, Ph.D, and TA positions are available!!!
We invite applications for Post-doc, Ph.D, and TA positions. The research will use iPSCs-derived brain organoids as a model system to dissect cilia/centrosome biology in human brain development and pathogenesis of glioblastoma and personalized glioma invasion assays. Projects involve cutting-edge techniques such as high-resolution imaging, next-generation sequencing, multi-omics, and next-generation organoid culturing. Doctoral students will readily be enrolled in molecular medicine programs. If you are interested, please refer to our papers and send your CV, research, and career interest as a single PDF file directly to Jay Gopalakrishnan (jay.gopalakrishnan@uni-jena.de)
From September 2024, The CCB lab will be operational at the Institute of Human Genetics, University Hospital, Jena!!
September 2023
FOR5547 is approved !!. Excellent teamwork by a group of cilia labs.
DFG Funds Eight New Research Units and one of them is ours!!
https://www.dfg.de/en/service/press/press_releases/2023/press_release_no_40/index.html
How do cells assemble into tissues and keep them intact? This is what the Research Unit “Deciphering the Role of Primary Ciliary Dynamics in Tissue Organization and Function” would like to determine. The researchers focus on the primary cilia–cell components that protrude from the surface of cells and perceive and transmit signals. They play a crucial role in developing and organizing tissues in a healthy and diseased state. The research unit combines specialists from cell and developmental biology, biophysics and biochemistry, and medicine to find out more about how they work. Using various methods and models, they will jointly investigate the cilia in different cell types. (Spokesperson: Professor Dr. Jay Gopalakrishnan, HHU Düsseldorf)
January 2023
Glioma-PerMed
Glioma invasion assays as a predictive tool for personalized glioma medicine.
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